A broadly protective antibody
نویسندگان
چکیده
منابع مشابه
Toward a broadly protective influenza vaccine.
The current inactivated influenza virus vaccines induce antibodies that protect against closely related virus strains. They do not, however, protect against antibody-escape variants of seasonal influenza A viruses or new pandemic influenza A viruses emerging from non-human reservoirs. Might boosting influenza A virus-specific CD8+ T cell memory diminish the danger posed by these variant viruses...
متن کاملA broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
Influenza B virus (IBV) causes annual influenza epidemics around the world. Here we use an in vivo plasmablast enrichment technique to isolate a human monoclonal antibody, 46B8 that neutralizes all IBVs tested in vitro and protects mice against lethal challenge of all IBVs tested when administered 72 h post infection. 46B8 demonstrates a superior therapeutic benefit over Tamiflu and has an addi...
متن کاملCorrigendum: A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
This corrects the article DOI: 10.1038/ncomms14234.
متن کاملProspects for Broadly Protective Influenza Vaccines.
The development of vaccines that could provide broad protection against antigenically variant influenza viruses has long been the ultimate prize in influenza research. Recent developments have pushed us closer to this goal, and such vaccines may now be within reach. This brief review outlines the current approaches to broadly protective vaccines, and the probable hurdles and roadblocks to achie...
متن کاملGeneration of a serum free CHO DG44 cell line stably producing a broadly protective anti-influenza virus monoclonal antibody
Because of the broad neutralization and in vivo protection across influenza A and influenza B virus strains, monoclonal antibody CR9114 is widely used in influenza virus research as a positive control in many experiments. To produce amounts sufficient for the demand requires regular transient transfections, resulting in varying yield as well as differing batch to batch quality. Here, we report ...
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ژورنال
عنوان ژورنال: Nature
سال: 2017
ISSN: 0028-0836,1476-4687
DOI: 10.1038/551310a